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The HRA and Medicines and Healthcare products Regulatory Agency (MHRA) have been exploring opportunities to improve the service being offered for the approval and ongoing management of Clinical Trials of Medicinal Products (CTIMPs).

We see increased assimilation as a positive step forward. With that in mind we've launched a combined ways of working pilot to test an integrated process.

The pilot is currently open to applications by prior agreement only, with the expectation that it will be opened up to all CTIMP applications as it develops. If you are interested in submitting an application into this pilot, please email contact.hra@nhs.net and include ‘combined ways of working pilot’ in the subject line.

The pilot process requires a single CTIMP application dossier to be submitted for both the Clinical Trial Authorisation (CTA) and the Research Ethics Committee (REC) opinion. In England and Wales this will also incorporate HRA and HCRW Approval.

The process involves a single submission, combined communications to request any further information required and a single communication to confirm the final decision.   

Only certain RECs are involved in this pilot, although the number involved continues to increase. 

The most up-to-date information about which RECs are taking part in the pilot and when they meet will always be included in the REC meeting schedule below

Each REC meeting has a submission period within which applications must be submitted. Applications into the pilot must be received during the submission period for any chosen REC, otherwise the application will be allocated to the next available REC meeting. 

Please note the reservation of slots in advance is required to increase the chance of the meeting having availability.

REC name Submission open Submission closed Meeting date
Bristol Central 10 Nov 2018 16 Nov 2018 30 Nov 2018
05 Jan 2019 11 Jan 2019 25 Jan 2019
02 Feb 2019 08 Feb 2019 22 Feb 2019
09 Mar 2019 15 Mar 2019 29 Mar 2019
Sheffield 13 Nov 2018 19 Nov 2018 03 Dec 2018
25 Dec 2018 31 Dec 2018 14 Jan 2019
12 Feb 2019 18 Feb 2019 04 Mar 2019
Cambridge and Hertfordshire 25 Oct 2018 31 Oct 2018 14 Nov 2018
22 Nov 2018 28 Nov 2018 12 Dec 2018
24 Jan 2019 30 Jan 2019 13 Feb 2019
21 Feb 2019 27 Feb 2019 13 Mar 2019
West of Scotland REC 1 17 Oct 2018 23 Oct 2018 06 Nov 2018
14 Nov 2018 20 Nov 2018 04 Dec 2018
16 Jan 2019 22 Jan 2019 05 Feb 2019
13 Feb 2019 19 Feb 2019 05 Mar 2019
London- Hampstead 25 Oct 2018 31 Oct 2018 14 Nov 2018
22 Nov 2018 28 Nov 2018 12 Dec 2018
20 Dec 2018 26 Dec 2018 09 Jan 2019
24 Jan 2019 30 Jan 2019 13 Feb 2019
Manchester Central 20 Nov 2018 26 Nov 2018 10 Dec 2018
22 Dec 2018 28 Dec 2018 14 Jan 2019
19 Feb 2019 25 Feb 2019 11 Mar 2019
North West- Haydock 24 Oct 2018 30 Oct 2018 13 Nov 2018
21 Nov 2018 27 Nov 2018 11 Dec 2018
23 Jan 2019 29 Jan 2019 12 Feb 2019
20 Feb 2019 26 Feb 2019 12 Mar 2019
Berkshire B 24 Oct 2018 30 Oct 2018 13 Nov 2018
21 Nov 2018 27 Nov 2018 11 Dec 2018
15 Dec 2018 21 Dec 2018 08 Jan 2019
23 Jan 2019 29 Jan 2019 12 Feb 2019
Leeds East 14 Nov 2018 20 Nov 2018 4 Dec 2018
15 Jan 2019 22 Jan 2019 05 Feb 2019
13 Feb 2019 19 Feb 2019 05 Mar 2019
London Surrey Borders 01 Nov 2018 07 Nov 2018 21 Nov 2018
27 Dec 2018 02 Jan 2019 16 Jan 2019
31 Jan 2019 06 Feb 2019 20 Feb 2019
28 Feb 2019 06 Mar 2019 20 Mar 2019
Health and Social Care REC A 6 Nov 2018 13 Nov 2018 27 Nov 2018
27 Nov 2018 4 Dec 2018 18 Dec 2018
09 Jan 2019 15 Jan 2019 29 Jan 2019
07 Feb 2019 12 Feb 2019 26 Feb 2019
06 Mar 2019 12 Mar 2019 26 Mar 2019
Health and Social Care REC B 19 Oct 2018 25 Oct 2018 8 Nov 2018
27 Dec 2019 03 Jan 2019 17 Jan 2019
25 Jan 2019 31 Jan 2019 14 Feb 2019
22 Feb 2019 28 Feb 2019 14 Mar 2019
Yorkshire and the Humber - Sheffield 16 Oct 18 22 Oct 2018 05 Nov 2018
13 Nov 18 19 Nov 2018 03 Dec 2018
25 Dec 18 31 Dec 18 14 Jan 2019
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