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This page contains information for participants who would like to submit a Clinical Trials of Medicinal Products (CTIMPs) application via the Combined Ways of Working (CWoW). We are now accepting applications from new sponsor organisations from January 2021. To express an interest, please email cwow@hra.nhs.uk.

PLEASE NOTE: Applications which are being submitted via the CWoW must be submitted using a new part of Integrated Research Application System (IRAS) and therefore applications should not be started in the standard part of IRAS.

The Combined Ways of Working process

The Combined Ways of Working (CWoW) sees the HRA working closely with colleagues in the Medicines and Healthcare products Regulatory Agency (MHRA) and across the devolved administrations to develop a single application route and a coordinated ethics and regulatory review leading to a single UK decision on a clinical trial. For more information, see the Combined Ways of Working page.

Introduction to CWoW video

You can watch a presentation on Introducing CWoW on our Learning Management System platform.
To access the video, you will need to register for an account on the Learning Management System.

Participating Research Ethics Committees

Only certain RECs are involved in the CWoW process currently, although the number involved continues to increase. 

The most up-to-date information about which RECs are taking part and when they meet will always be included in the REC meeting schedule below.

Each REC meeting has a submission period within which applications must be submitted. Applications into the CWoW process must be received during the submission period for any chosen REC, otherwise the application will be allocated to the next available REC meeting. Please note the reservation of slots in advance is required to increase the chance of the meeting having availability.The most up-to-date information about which Research Ethics Committees (RECs) are taking part in the pilot and when they meet will always be included in the REC meeting schedule below.

Each REC meeting has a submission period within which applications must be submitted. Applications into CWoW must be received during the submission period for any chosen REC, otherwise the application will be allocated to the next available REC meeting. Please note the reservation of slots in advance is required to increase the chance of the meeting having availability.

Committees currently accepting CWoW applications

Please note, the below is a list of the submission and meeting dates but does not reflect slot availability. Please follow the reservation instructions set out in the sponsor instruction document.

REC name Submission open Submission closed Meeting date
Bristol Central 9 Apr 2021 16 Apr 2021 30 Apr 2021
Bristol Central 7 May 2021 14 May 2021 28 May 2021
Bristol Central 9 July 2021 16 July 2021 30 July 2021
Leeds West 21 May 2021 28 May 2021 11 June 2021
Leeds West 18 June 2021 25 June 2021 9 July 2021
London Westminster 6 Apr 2021 13 Apr 2021 27 Apr 2021
London Westminster 8 June 2021 15 June 2021 29 June 2021
London Westminster 6 July 2021 13 July 2021 27 July 2021
London Hampstead 21 Apr 2021 28 Apr 2021 12 May 2021
London Hampstead 19 May 2021 26 May 2021 09 June 2021
London Hampstead 23 June 2021 30 June 2021 14 July 2021
East of Scot REC 2 29 Apr 2021 5 May 2021 19 May 2021
East of Scot REC 2 11 May 2021 18 May 2021 1 June 2021
East of Scot REC 2 15 June 2021 22 June 2021 6 July 2021
West of Scot REC 1 13 Apr 2021 20 Apr 2021 04 May 2021
West of Scot REC 1 11 May 2021 18 May 2021 01 June 2021
West of Scot REC 1 15 June 2021 22 June 2021 06 July 2021
Hampshire A 20 Apr 2021 27 Apr 2021 11 May 2021
Hampshire A 18 May 2021 25 May 2021 08 June 2021
Hampshire A 22 June 2021 29 June 2021 13 July 2021
Oxford A 17 Apr 2021 23 Apr 2021 07 May 2021
Oxford A 14 May 2021 21 May 2021 04 June 2021
Oxford A 11 June 2021 18 June 2021 02 July 2021
Manchester Central 19 Apr 2021 26 Apr 2021 10 May 2021
Manchester Central 24 May 2021 31 May 2021 14 June 2021
North West- Haydock 20 Apr 2021 27 Apr 2021 11 May 2021
North West- Haydock 18 May 2021 25 May 2021 08 June 2021
North West- Haydock 22 June 2021 29 June 2021 13 July 2021
Leeds East 19 Apr 2021 26 Apr 2021 10 May 2021
Leeds East 17 May 2021 24 May 2021 7 June 2021
Health and Social Care REC A 6 Apr 2021 13 Apr 2021 27 Apr 2021
Health and Social Care REC A 4 May 2021 11 May 2021 25 May 2021
Health and Social Care REC A 8 June 2021 15 June 2021 29 June 2021
Health and Social Care REC B 15 April 2021 22 April 2021 06 May 2021
Health and Social Care REC B 20 May 2021 27 May 2021 10 June 2021
Health and Social Care REC B 17 June 2021 24 June 2021 8 July 2021
North East York 16 Apr 2021 23 Apr 2021 7 May 2021
North East York 14 May 2021 21 May 2021 04 June 2021
North East York 11 June 2021 18 June 2021 02 July 2021
Berkshire B 23 Mar 2021 30 Mar 2021 13 Apr 2021
Berkshire B 18 May 2021 25 May 2021 8 June 2021
Berkshire B 22 June 2021 29 June 2021 13 July 2021
Cambridge and Herts 21 Apr 2021 28 Apr 2021 12 May 2021
Cambridge and Herts 12 May 2021 19 May 2021 09 June 2021
Cambridge and Herts 16 June 2021 23 June 2021 14 July 2021
London Surrey Borders 31 Mar 2021 07 Apr 2021 21 Apr 2021
London Surrey Borders 28 Apr 2021 05 May 2021 19 May 2021
London Surrey Borders 27 May 2021 02 June 2021 16 June 2021
London Surrey Borders 01 July 2021 07 July 2021 21 July 2021
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