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The HRA and Medicines and Healthcare products Regulatory Agency (MHRA) have been exploring opportunities to improve the service being offered for the approval and ongoing management of Clinical Trials of Medicinal Products (CTIMPs).

We see increased assimilation as a positive step forward. With that in mind we've launched a combined ways of working pilot to test an integrated process.

The pilot is currently open to applications by prior agreement only, with the expectation that it will be opened up to all CTIMP applications as it develops. If you are interested in submitting an application into this pilot, please email cwow.admin@nhs.net and include ‘combined ways of working pilot’ in the subject line.

The pilot process requires a single CTIMP application dossier to be submitted for both the Clinical Trial Authorisation (CTA) and the Research Ethics Committee (REC) opinion. In England and Wales this will also incorporate HRA and Health and Care Research Wales (HCRW) Approval.

The process involves a single submission, combined communications to request any further information required and a single communication to confirm the final decision.   

Only certain RECs are involved in this pilot, although the number involved continues to increase. 

The most up-to-date information about which RECs are taking part in the pilot and when they meet will always be included in the REC meeting schedule below

Each REC meeting has a submission period within which applications must be submitted. Applications into the pilot must be received during the submission period for any chosen REC, otherwise the application will be allocated to the next available REC meeting. Please note the reservation of slots in advance is required to increase the chance of the meeting having availability.

Please note the reservation of slots in advance is required to increase the chance of the meeting having availability.

Key guidance and documents

Key dates

REC name Submission open Submission closed Meeting date
Bristol Central 09 Aug 2019 16 Aug 2019 30 Aug 2019
06 Sep 2019 13 Sep 2019 27 Sep 2019
04 Oct 2019 11 Oct 2019 25 Oct 2019
08 Nov 2019 15 Nov 2019 29 Nov 2019
10 Jan 2020 17 Jan 2020 31 Jan 2020
07 Feb 2020 14 Feb 2020 28 Feb 2020
Camb and Herts 21 Aug 2019 28 Aug 2019 11 Sep 2019
23 Oct 2019 30 Oct 2019 13 Nov 2019
20 Nov 2019 27 Nov 2019 11 Dec 2019
22 Jan 2020 29 Jan 2020 12 Feb 2020
West of Scotland REC 1 13 Aug 2019 20 Aug 2019 03 Sep 2019
10 Sep 2019 17 Sep 2019 01 Oct 2019
15 Oct 2019 22 Oct 2019 05 Nov 2019
12 Nov 2019 19 Nov 2019 03 Dec 2019
London Hampstead 21 Aug 2019 28 Aug 2019 11 Sep 2019
18 Sep 2019 25 Sep 2019 09 Oct 2019
23 Oct 2019 30 Oct 2019 13 Nov 2019
20 Nov 2019 27 Nov 2019 11 Dec 2019
Oxford A 16 Aug 2019 23 Aug 2019 06 Sep 2019
11 Oct 2019 18 Oct 2019 01 Nov 2019
15 Nov 2019 22 Nov 2019 06 Dec 2019
17 Jan 2020 24 Jan 2020 07 Feb 2020
Mancehster Central 19 Aug 2019 26 Aug 2019 09 Sep 2019
23 Sep 2019 30 Sep 2019 14 Oct 2019
18 Nov 2019 25 Nov 2019 09 Dec 2019
23 Dec 2019 30 Dec 2019 13 Jan 2020
20 Jan 2020 27 Jan 2020 10 Feb 2020
North West- Haydock 20 Aug 2019 27 Aug 2019 10 Sep 2019
17 Sep 2019 24 Sep 2019 08 Oct 2019
22 Oct 2019 29 Oct 2019 12 Nov 2019
21 Nov 2019 28 Nov 2019 12 Dec 2019
Leeds East 12 Aug 2019 19 Aug 2019 02 Sep 2019
15 Jul 2019 22 Jul 2019 05 Aug 2019
16 Sep 2019 23 Sep 2019 07 Oct 2019
14 Oct 2019 21 Oct 2019 04 Nov 2019
11 Nov 2019 18 Nov 2019 02 Dec 2019
13 Jan 2020 20 Jan 2020 03 Feb 2020
10 Feb 2020 17-Feb 2020 02 Mar 2020
Health and Social Care REC A 30 Jul 2019 06 Aug 2019 20 Aug 2019
03 Sep 2019 10 Sep 2019 24 Sep 2019
01 Oct 2019 08 Oct 2019 22 Oct 2019
29 Oct 2019 05 Nov 2019 19 Nov 2019
26 Nov 2019 03 Dec 2019 17 Dec 2019
Health and Social Care REC B 15 Aug 2019 22 Aug 2019 05 Sep 2019
12 Sep 2019 19 Sep 2019 03 Oct 2019
17 Oct 2019 24 Oct 2019 07 Nov 2019
14 Nov 2019 21 Nov 2019 05 Dec 2019
North East- York 20 Sep 2019 27 Sep 2019 11 Oct 2019
11 Oct 2019 18 Oct 2019 01 Nov 2019
15 Nov 2019 22 Nov 2019 06 Dec 2019
13 Dec 2019 20 Dec 2019 03 Jan 2020
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