WiTXI study
Research type
Research Study
Full title
A randomised paired design study of Texture and Colour Enhancement Imaging (TXI) versus high definition white light endoscopy for dysplasia detection in IBD surveillance.
IRAS ID
345437
Contact name
Jonathan Landy
Contact email
Sponsor organisation
London North West University Healthcare NHS Trust
Duration of Study in the UK
1 years, 2 months, 29 days
Research summary
Bowel cancer in people with inflammatory bowel disease (IBD) often starts from abnormal changes in the cells lining the bowel, known as dysplasia. International guidelines recommend undertaking regular camera tests of the bowel (colonoscopies) to check for precancerous changes in IBD patients. In the past, these precancerous changes were thought to be invisible, but with better camera imaging technology, most cases of these early changes can now be seen. However, it is still very difficult to find early precancerous changes as they often appear as small, flat, subtle lesions.
Important studies have shown that using a dye applied to the bowel lining during the camera test can help detect early changes better than standard colonoscopy. However, there are challenges to using dye, such as the extra preparation time needed, and the learning curve for the technique. Newer high-definition cameras (colonoscopes) have shown higher detection rates compared to the older standard cameras. Advances in imaging technology have also led to the creation of new techniques to better detect and identify abnormal tissues. One such technique is Texture and Colour Enhancement Imaging (TXI), which improves texture, brightness, and colour in high-definition cameras, making it easier to see small, subtle differences in tissue. This push-button technology is now available with the EVIS X1
system (Olympus) of colonoscopes which are used in regular clinical practice.There are no randomised data regarding the utility of TXI for detection of dysplasia in colonoscopy for IBD surveillance. We propose to undertake a randomised paired design study of Texture and Colour Enhancement Imaging (TXI) versus high definition wight light endoscopy for the detection of dysplasia in IBD surveillance.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
25/EM/0266
Date of REC Opinion
9 Jan 2026
REC opinion
Further Information Favourable Opinion