Within-participant predictors of adherence to oral HIV PrEP
Research type
Research Study
Full title
'Psychological and behavioural within-participant predictors of adherence to oral HIV Pre Exposure Prophylaxis (PrEP)'
IRAS ID
224366
Contact name
Alison Taylor
Contact email
Sponsor organisation
Doctorate in Clinical Psychology, Royal Holloway University of London
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
The use of Pre-exposure prophylaxis (PrEP) is the use of antiretroviral drugs to prevent HIV infection/transmission. PrEP requires optimal adherence to be successful in HIV prevention. Factors which influence non-adherence are critical to understanding medication management and informing intervention development, particularly within the HIV negative population whom do not have immediate benefits from treatment. This study aims to investigate within-participant situational differences in adherent and non-adherent episodes, informed by theory (the Information-Motivation-Behavioural Skills [IMB] model) in a cross sectional study about retrospective adherence episodes. All participants will be HIV negative adults whom are at high risk of HIV acquisition. The sample may include longer-term PrEP users as well as new PrEP users who have been using PrEP for at least a three-month period. Specifically, the sample will include men who have sex with men (MSM) who, in the context of a daily dosing regimen, show evidence of inconsistent adherence in the previous month, i.e. one day when a dose was taken and one day a dose wasn’t taken within the last month. By understanding the variables which influence PrEP adherence and non-adherence it is hoped that these can contribute to the development of effective adherence interventions.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
17/LO/0625
Date of REC Opinion
2 Jun 2017
REC opinion
Further Information Favourable Opinion