WIN-HD

• Research type

  Research Study

• Full title

  Decoding Pre-symptomatic white matter changes in Huntington’s Disease

• IRAS ID

  229730

• Contact name

  Sarah Tabrizi

• Contact email

  s.tabrizi@ucl.ac.uk

• Sponsor organisation

  University College London Hospitals NHS Foundation Trust

• Clinicaltrials.gov Identifier

  Z6364106/2017/08/22 , UCL data registration number

• Duration of Study in the UK

  1 years, 11 months, 31 days

• Research summary

  The primary aim of WIN-HD study is to detect white matter changes, such as changes in volume and distribution, far from the onset of the symptoms in Huntington’s disease mutation carriers. 30 participants will be included in this study – 15 people with the HD genetic mutation and 15 healthy controls- and they will be asked to attend two study visits, 12 months apart, where MRI scans and neuropsychiatric assessments will be undertaken.
  The results of this study will help us to understand white-matter and behaviour changes in the early stages of HD, and will enable us to develop/optimize MRI scan techniques to study white-matter changes in this population.

• REC name

  London - Riverside Research Ethics Committee

• REC reference

  17/LO/1438

• Date of REC Opinion

  29 Sep 2017

• REC opinion

  Further Information Favourable Opinion