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Why does Clozapine cause weight gain?

  • Research type

    Research Study

  • Full title

    Why does Clozapine cause Weight Gain? A Multilevel Examination of the Potential Mechanisms of Weight Gain



  • Contact name

    Hisham Ziauddeen

  • Contact email

  • Sponsor organisation

    University of Cambridge and Cambridgeshire and Peterborough Foundation Trust

  • Research summary

    Clozapine is the only second line treatment for schizophrenia. It however causes weight gain in 75% of patients, with a third experiencing more than 7% weight gain over 3 years. Why this happens is unclear. We believe that to investigate this requires an integrated approach that simultaneously examines multiple possible factors including genetic, metabolic and brain mechanisms. We propose to use such an approach and contrast patients who gain significant weight on clozapine (“vulnerable”) to those who gain little or no weight (“protected”). Our aim is to identify risk factors and develop treatments for clozapine related weight gain.

  • REC name

    East of England - Cambridge Central Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    23 Sep 2013

  • REC opinion

    Favourable Opinion