What aspects of nutritional status are compromised in Crohn's patients
Research type
Research Study
Full title
What aspects of nutritional status are compromised in Crohn's disease patients requiring surgical intervention
IRAS ID
168332
Contact name
Miranda Lomer
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust
Duration of Study in the UK
2 years, 6 months, 0 days
Research summary
Crohn’s disease is an inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract. It is extremely debilitating, often requires gastrointestinal resection to remove diseased bowel and has a negative impact on nutritional status. As part of routine clinical practice at Guy’s and St Thomas’ NHS Foundation Trust, patients with Crohn’s disease undergoing gastrointestinal resection will have a comprehensive assessment of their nutritional status. Following ethical approval, we propose a prospective study to assess the nutritional status of patients with Crohn’s disease (surgical and non-surgical), patients with ulcerative colitis (surgical and non-surgical), and healthy controls to compare and to determine whether there are any specific aspects of nutritional status that are compromised in patients with Crohn’s disease undergoing gastrointestinal resection.
Current National and International recommendations advise that nutritional assessment is carried out on all IBD patients. Despite this, there is no study comparing the subtypes of patients (surgical compared to non-surgical) we aim to enrol. Therefore we hope this study will provide valuable information both to justify the recommendations, and to provide further information with respect to prevalence of abnormalities.
Reference:
Spinelli A, Allocca M, Jovani M, Danese S.Review article: optimal preparation for surgery in Crohn’s disease. Aliment Pharmacol Ther 2014; 40: 1009–1022REC name
London - Stanmore Research Ethics Committee
REC reference
15/LO/0219
Date of REC Opinion
20 Mar 2015
REC opinion
Further Information Favourable Opinion