Weight loss as predictor of mortality in patients with IPF
Research type
Research Study
Full title
Weight loss as predictor of mortality in patients with Idiopathic Pulmonary Fibrosis: a retrospective study
IRAS ID
255156
Contact name
Roksolana Starodub
Contact email
Sponsor organisation
King’s College London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 6 months, 24 days
Research summary
Idiopathic Pulmonary Fibrosis (IPF) is the most common form of interstitial lung diseases (ILD). It is a chronic, progressive and life limiting condition which is associated with fatal prognosis, resulting in significant morbidity and mortality. The aim of this empirical study is to find out if weight loss predict mortality in patients with Idiopathic Pulmonary Fibrosis (IPF). The study is an exploratory, retrospective study using secondary data.
No previous studies have specifically investigated weight loss as a predictor of mortality in patients with IPF nor has it been considered to be prognostic factor. One study looked at body mass index and found that a higher BMI has a better survival in IPF patients and an another study reported that Fat-Free mass index (FFMI) in IPF patients is a significant independent predictor of survival. This retrospective study will investigate whether weight loss has an independent effect on survival in IPF.
Secondary data will be collected retrospectively on a representative sample of adult patients diagnosed with IPF aged over 18 years old, at a tertiary care NHS teaching hospital, in London (UK) between 2006 and 2018. The projected date to start data collection is January 2019 and complete data collection by May 2019. The entire dissertation will be a 1 year process starting from October 2018 till September 2019.
REC name
London - Stanmore Research Ethics Committee
REC reference
19/LO/0193
Date of REC Opinion
19 Feb 2019
REC opinion
Favourable Opinion