VTE risk in GCT patients receiving L1 chemotherapy

• Research type

  Research Study

• Full title

  Risk of Venous Thromboembolism in Patients Receiving First-Line Chemotherapy for Disseminated Germ Cell Tumours – a Multi-Site Retrospective Cohort Study as part of the Global Germ-Cell Cancer Group (G3) Consortium

• IRAS ID

  191430

• Contact name

  Alison Reid

• Sponsor organisation

  The Royal Marsden NHS Foundation Trust

• Clinicaltrials.gov Identifier

  CCR4461, CCR number

• Duration of Study in the UK

  0 years, 8 months, 0 days

• Research summary

  A recent study published by Srikanthan and Tran et al. JCO 2014 has demonstrated that the presence of large (>5cm in axial diameter) retroperitoneal lymph node metastases (secondaries in the abdomen) on baseline CT scans are associated with significantly increased risk of venous thromboembolism (clots) in patients receiving first line chemotherapy for disseminated germ cell tumours.
  This study, a collaborative effort of an international testis research groups consortium, aims to confirm these findings in a large multi-national, retrospective, validation cohort. The Royal Marsden Hospital is one of the major international collaborators in this project.

• REC name

  South Central - Oxford C Research Ethics Committee

• REC reference

  16/SC/0031

• Date of REC Opinion

  14 Jan 2016

• REC opinion

  Favourable Opinion