VR lead in pulmonary hypertension
Research type
Research Study
Full title
Assessing the efficacy of leads V4/3R during cardiopulmonary exercise test to detect right ventricular ischaemia in pre-capillary pulmonary hypertension
IRAS ID
192995
Contact name
Alistair Church
Contact email
Sponsor organisation
National Waiting Times Centre Board
Duration of Study in the UK
0 years, 7 months, 4 days
Research summary
The study aims to understand if the addition of the V4R and V3R lead in patients with pulmonary hypertension helps to identify right ventricular hypertrophy and ischaemia in those patients. Patients with high blood pressure in the lungs (pulmonary hypertension) develop increased thickness of the main pumping chamber in the right side of the heart. This can also lead to disruption of the blood flow to the right ventricle and can lead to worsening right ventricular function. These patients as part of routine investigations for pulmonary hypertension undergo a bicycle exercise test called a cardiopulmonary exercise test(CPET). They normally have a 12 lead ECG attached to their chest on the left side which measures the electrical activity of the left heart. A 12 –lead ECG records the heart rhythm during CPET, using adhesive electrodes (leads) attached to the chest wall. The standard placement of these leads is on the left chest wall. To look at the right side of the heart, 2 leads (V3R and V4R) will be placed across the right chest wall, allowing better assessment of the electrical activity of the right side of the heart This V4R/V3R lead would be attached on the right side of the chest and will allow better identification of the electrical activity of the right side of the heart. This can be used to measure an increase in the size of the right side of the heart muscle and detect any issue with blood flow to the right side. This may allow a better method of detecting right heart hypertrophy(enlargement) and ischaemia(poor blood supply) and the changes in the electrical activity will be correlated to other measure of disease activity to see if there is a link.
REC name
West of Scotland REC 4
REC reference
16/WS/0098
Date of REC Opinion
11 May 2016
REC opinion
Favourable Opinion