Volatile organic compounds during infusion of propofol V.02
Research type
Research Study
Full title
Characterisation and validation of volatile organic compound sensing using optical interrogation of metal-organic frameworks in breath during intravenous infusion of propofol
IRAS ID
322996
Contact name
Sergiy Korposh
Contact email
Sponsor organisation
University of Nottingham
Clinicaltrials.gov Identifier
EP/V055410/1, project number
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
In this study, we wish to identify and measure the components of human breath. This will help us to have a better knowledge of how quickly anaesthetic compounds break down and also to understand whether some of the substances present in breath change during surgery and whether we can use this to monitor a patient’s condition.
Propofol is a widely used agent of sedation and general anaesthesia. It is given intravenously during surgery. Despite its common use, there is no clinically feasible way to measure, in real time, propofol concentrations in body tissues. Anaesthetists therefore use clinical experience to estimate body propofol concentrations. They use these estimates to adjust the amount of drug they administer to patients. This can result in underdosing (leading to inadequate depth of anaesthesia and accidental awareness under anaesthesia) or overdosing. In this work, we will use a new type of sensor to identify and measure some compounds present in the breath and in blood from patients undergoing general anaesthesia using propofol. We will observe whether a relationship exists between the doses of drug administered, the clinical estimates of the amount of propofol in blood and the actual amounts measured in blood concentrations of other simple substances observed using the new sensors. The results of this work will enable us to develop new methods for measuring the amount of propofol more accurately.
REC name
North West - Greater Manchester West Research Ethics Committee
REC reference
23/NW/0353
Date of REC Opinion
2 Jan 2024
REC opinion
Further Information Favourable Opinion