VMN-NIV
Research type
Research Study
Full title
Effects of vibrating mesh nebulisation in patients with COPD during non-invasive ventilation (VMN-NIV): a pilot randomised crossover trial
IRAS ID
348845
Contact name
Eui-Sik Suh
Contact email
Sponsor organisation
Guy's and St Thomas' NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
People with COPD using non-invasive ventilation frequently need to use nebulisers with salbutamol to help their breathing and secretions either at home or when unwell in hospital. It is currently unclear if giving medications through the different nebuliser technology has an improved impact on the neural respiratory drive or if it can improve breathlessness.
This study is investigating two types of nebuliser that are both used routinely within clinical practice. The two nebulisers a) a jet nebuliser which blows air or oxygen through the liquid medicine to turn it into a spray to be breathed into the lungs b) a vibrating mesh nebulisers that vibrates to create small droplets of the liquid medicine to be breathed into the lungs. Both types of nebulisers are available commercially and have been through extensive safety testing they have different mechanisms of delivering the medication into the lungs.
This is a feasibility, randomised crossover study which will be conducted at a single site and we are aiming to recruit 12 patients (allowing for 18 participants to allow for drop outs). Participants will attend two outpatient visits where they will have baseline information recorded and different tests to assess breathing before and during one hour after receiving salbutamol during non-invasive ventilation via one of the nebuliser types. The process will be repeated and they will receive salbutamol via the other nebuliser type on the second visit.
We are now conducting this study to determine if there is a difference in the mechanics of breathing following being given saline and salbutamol by the two different nebulisers for patients with COPD during non-invasive ventilation.We hope this study will inform the design and development of a full multi-centre randomised control trial to assess whether giving medications through different nebuliser technologies has a clinical benefit to patients who require non-invasive ventilation.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
25/EM/0023
Date of REC Opinion
17 Feb 2025
REC opinion
Favourable Opinion