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Vitamin D Level in Nasal Polyposis: A pilot study Version 1.0

  • Research type

    Research Study

  • Full title

    Vitamin D Level in Nasal Polyposis: A pilot study

  • IRAS ID

    156403

  • Contact name

    Gaurav Chawdhary

  • Contact email

    gauravchawdhary@gmail.com

  • Sponsor organisation

    Great Western Hospitals NHS Foundation Trust

  • Duration of Study in the UK

    1 years, 0 months, 0 days

  • Research summary

    Nasal polyposis is an inflammatory condition of the nose and sinuses. It is usually treated with steroid nose sprays and cannot be cured, only controlled. In severe cases, surgery is performed to open the sinuses in the nose and improve symptoms. Recently there have been reports from the USA, Taiwan and Turkey that have found low Vitamin D levels in patients with nasal polyposis. We want to see if this association is found in the UK population. We aim to determine the Vitamin D level in up to 30 patients with nasal polyposis in order to estimate the proportion of this population that is Vitamin D deficient and compare our pilot results with nationally available estimates of Vitamin D in the general population. Further, we aim to generate evidence that would either support or contrast with the work of other international groups, thereby adding to the body of knowledge in this fledgling field of research. Thirdly, this work would inform our subsequent decisions about the feasibility of pursuing any future work on this topic. The broader long-term vision is that if an association is confirmed, and causality demonstrated in further studies between low Vitamin D level and nasal polyposis, it could provide a new avenue for treatment that is simple, safe and already available: namely Vitamin D supplementation.

  • REC name

    East Midlands - Nottingham 1 Research Ethics Committee

  • REC reference

    15/EM/0193

  • Date of REC Opinion

    22 May 2015

  • REC opinion

    Further Information Favourable Opinion