Visual and Patient Outcomes with Trifocal vs Spiral Optic IOLs
Research type
Research Study
Full title
Visual and Patient reported outcomes of a diffractive trifocal and a non-diffractive spiral optic presbyopia-correcting intraocular lens: a randomized controlled trial
IRAS ID
366611
Contact name
Vincenzo Maurino
Contact email
Sponsor organisation
Moorfields Eye Hospital NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 30 days
Research summary
This study will compare two CE-marked presbyopia-correcting intraocular lenses (IOLs) that are routinely used during cataract surgery: the Clareon PanOptix Trifocal IOL (Alcon) and the RayOne Galaxy IOL (Rayner). Both devices are already approved and used within their intended purpose, which is to replace the natural lens after cataract extraction and improve vision at different distances.
Adults with bilateral cataract who are already scheduled for NHS cataract surgery at Moorfields will be invited to participate. After giving consent and confirming eligibility, participants will be randomly allocated to receive one of the two IOLs in both eyes. All surgery will follow standard clinical practice.
The study aims to compare vision at near, intermediate and distance, refractive accuracy, visual quality, and patient-reported outcomes. All tests use non-invasive, routinely used ophthalmic assessments. Follow-up lasts 3 months after the second eye surgery.
The risks of participation are the same as those of normal cataract surgery, and no experimental procedures are added. The study may help improve clinical decision-making about presbyopia-correcting IOLs and provide much-needed comparative data on the RayOne Galaxy lens, for which limited published evidence currently exists.
REC name
South Central - Hampshire A Research Ethics Committee
REC reference
26/SC/0045
Date of REC Opinion
12 Mar 2026
REC opinion
Further Information Favourable Opinion