VISION - Natural History Study of Dry AMD
Research type
Research Study
Full title
A natural history study to evaluate the progression of Dry Age-Related Macular Degeneration (AMD)
IRAS ID
267125
Contact name
Giuliana Silvestri
Contact email
Sponsor organisation
BHSCT
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
Age-related macular degeneration (AMD) is a multifactorial disease caused by both genetic and environmental factors. Geographic atrophy (GA) is a progressive form of dry AMD that is characterized by irreversible loss of macular retinal tissue, retinal pigment epithelium (RPE), and choriocapillaris. Oxidative stress, dysregulation of the complement system, and inflammation are thought to play pathophysiologic roles in the development and progression of AMD, although the relative contribution of each of these pathways and molecular mechanisms is not well established. Polymorphisms in the complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genes have the greatest impact on the progression to advanced AMD; however, evidence is emerging that other genes may also play a role in AMD development. In clinical studies, mean lesion progression rates vary widely among individuals, ranging from 1.2 to 2.8 mm2 per year. In this study we intend to analyze the progression rates of patients based on their clinical presentation and genetic predisposition
The study is a natural history observational study designed to assess the rate of progression of GA, appearance of HTD (Hyper transmission defect) iRORA, cRORA and drusen volume and size in patients with non-exudative AMD Information on related to patient genetic data will be collected for information only, and may be used in certain analyses of study data. This natural history study will be crucial for the determination of timings for intervention for future CFH-1 directed therapies.REC name
HSC REC B
REC reference
22/NI/0176
Date of REC Opinion
13 Dec 2022
REC opinion
Favourable Opinion