VILICD98 Version 02
Research type
Research Study
Full title
Regulation of Ventilator Induced Lung Injury (VILI) by CD98 in Alveolar Epithelial Cells
IRAS ID
174022
Contact name
Richard Beale
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust R&D Department
Duration of Study in the UK
0 years, 3 months, 28 days
Research summary
The proposed research focuses on regulation of mechanotransduction by CD98 in alveolar epithelial cells. Mechanotransduction highlights the response of intracellular signalling to external forces like stretch. Mechanical ventilation itself has been shown to induce lung injury in critically ill patients through mechanotransduction and CD98 appears to be involved in this process. The hypothesis is that increased expression of CD98 on the cell surface will heighten pre-existing pro-inflammatory responses of epithelial cells to mechanical stretch. This results in the release of pro-inflammatory mediators like IL-8 driving acute lung injury and subsequent multi-organ failure, associated with a high mortality rate. Therefore, the idea is to identify the mechanism by which this occurs and investigate ways of potentially regulating it. There is great potential in the clinical validity of this project as it may introduce a method that improves prognosis through regulating inflammation and preventing further damage.
REC name
London - South East Research Ethics Committee
REC reference
15/LO/1565
Date of REC Opinion
26 Oct 2015
REC opinion
Unfavourable Opinion