Cardio-oncology: A high resolution national electronic health record investigation of the interplay between cancer and heart disease – VICORI (the virtual cardio-oncology research initiative)
University of Leicester
Duration of Study in the UK
5 years, 0 months, 1 days
Although cancer and ischaemic heart disease remain the leading causes of death worldwide, improvements in treatments for both conditions have resulted in substantially increased rates of survival. As a result, a larger population of patients now live with both conditions. Yet, there are very limited data concerning the interplay between these two conditions, as well as approaches to their management. Long term cardiovascular sequelae in cancer survivors are recognised, but the longevity of outcomes precludes the design of clinical trials to investigate this and most cancer trials exclude patients with significant cardiovascular disease (and likewise most cardiovascular trials exclude cancer patients). It is therefore essential to generate longitudinal population cohort studies to improve our understanding of cardio-oncology. As well as refining current treatment, this will enable the identification of higher risk groups for clinical intervention (including the development of clinical trials) to avoid, treat, or prevent adverse interactions between cancer and its treatments and cardiovascular disease states.
We are a national research collaboration called VICORI (the virtual cardio-oncology research initiative) funded by the British Heart Foundation and Cancer Research UK and supported by: the British Cardiovascular Society; the British Cardiovascular Intervention Society; Macmillan Cancer Support; Public Health England; Independent Cancer Patients Voice; The NIHR Medical Informatics & Data Linkage (MIDL) Strategy Group; The British Cardio-Oncology Society and our patients. We are establishing a linked data resource containing information from patients with both heart disease and cancer so we can understand better how these common conditions interact. Importantly we will be using only data from which patient identities have been removed.
North East - Newcastle & North Tyneside 2 Research Ethics Committee
Date of REC Opinion
5 Apr 2018