VAS in ILD
Research type
Research Study
Full title
Visual analogue scores in interstitial lung disease
IRAS ID
188552
Contact name
Charles Sharp
Contact email
Sponsor organisation
North Bristol NHS Trust
Duration of Study in the UK
0 years, 10 months, 1 days
Research summary
Interstitial lung disease (ILD) is a diverse sub-specialty within respiratory medicine, in which there has been increasing interest over recent years as a result of a growing number of treatment options.
There is much debate and controversy over choice of outcome measures in clinical studies of interstitial lung disease (ILD). Objective measures of lung function such as Forced Vital Capacity (FVC) have been used in several landmark trials in Idiopathic Pulmonary Fibrosis (IPF), however their relevance to patients on a day-to-day basis is unproven. Specific quality of life questionnaires have also been developed, however these are onerous for patients to complete and take time to interpret and cannot be used easily in routine clinical practice.
Visual analogues scores (VAS) are patient reported measures used in a variety of areas, including pain and dyspnoea, and the visual analogue score (VAS) for dyspnoea has been validated in several other areas of respiratory medicine. VAS would be a valuable patient-centred clinical tool for both research and routine clinical use in ILD. This project aims to validate VAS for dyspnoea, cough and fatigue in ILD and also to determine the minimum clinically important difference (MCID) for a change in these score.
The Bristol Interstitial Lung Disease service reviews patients with ILD from across the South West of England. The study will aim to recruit an initial cohort of 100 patients with a clinical diagnosis of ILD, competent in English and with at least primary school education or equivalent, prior to their outpatient clinic review. A validation cohort of 30 patients will be recruited after the initial recruitment has been completed.
The study will be conducted in the Respiratory Physiology department and will require patients completing a 5- minute questionnaire in addition to their normal routine lung function tests.
REC name
East of Scotland Research Ethics Service REC 1
REC reference
15/ES/0196
Date of REC Opinion
17 Nov 2015
REC opinion
Favourable Opinion