Variation of physiological signals in newborn infants with HIE
Research type
Research Study
Full title
Heart rate, blood pressure, respiratory rate and oxygen saturation variability in newborn infants with hypoxic ischaemic encephalopathy (HIE). A retrospective observational study.
IRAS ID
166869
Contact name
Christopher Dewhurst
Contact email
Sponsor organisation
Liverpool Women's NHS Foundation Trust
Duration of Study in the UK
0 years, 6 months, 3 days
Research summary
Hypoxic Ischaemic Encephalopathy (HIE) occurs when blood and/or oxygen delivery to the fetus is reduced and results in multi organ injury including brain injury. Babies born with HIE are at risk of death in the first few days of life and those who survive are at risk of neurodevelopmental problems. Prognosis in the newborn period is based mainly upon the clinical condition and MRI scanning which is usually performed in the second week of life. Improved prognostication in the first few days of life will aid in identifying infants who are at high risk of neurodevelopmental problems, aiding parental counselling and decision making.
It has been observed that infants with HIE have abnromal physiological monitoring. Heart rate, blood pressure, respiratory rate and oxygen saturation are seen to have either a sinusoidal, rhythmic pattern or a flat tracing. These patterns in physiological monitoring are anecdotally considered as a marker of HIE severity. However, there has been no systematic evaluation comparing these physiological patterns with short and long term outcomes in infants with HIE.
All infants admitted in Liverpool Women’s Hospital since 2009 with HIE will be found from our clinical records and physiological monitoring will be studied and assess if they can predict babies' outcomes.
Aim
1. To review the presence of abnormal physiological patterns (heart rate, blood pressure, respiratory rate and oxygen saturation) in babies with HIE.
2. To assess if physiological patterns are associated with severity of HIE
3. To assess if these patterns are correlated with the 2 year outcome outcome for infants with HIE.REC name
London - South East Research Ethics Committee
REC reference
16/LO/0562
Date of REC Opinion
23 Mar 2016
REC opinion
Favourable Opinion