VALUeD, version 1.0

• Research type

  Research Study

• Full title

  Vascular Augmentation of Late-life Unremitted Depression

• IRAS ID

  64731

• Contact name

  Alan Thomas

• Sponsor organisation

  Gateshead Health NHS Foundation Trust

• Eudract number

  2010-023969-21

• ISRCTN Number

  0

• Clinicaltrials.gov Identifier

  0

• Research summary

  Depression has a high occurrence and causes other problems in older people, two-thirds of these patients will not have a lessening in their condition from routine treatment medication. About half have a form of depression known as ??vascular depression?. Augmentation, the addition to, antidepressant treatment with a vascular type of treatment (such as a group of a medications called Calcium Channel Blocker including the medication called amlodipine) may be effective in this group of patients but previously published studies have been from highly selected specific patient groups. We would like to find out if giving amlodipine medication to people with a late-life non-responding vascular type depression would be acceptable to this patient group. We would also like to know how they feel while having the treatment and whether this provides a measureable benefit for those patients and whether those benefits are relevant to the patients. We would also like to find out the information we need to plan and prepare for a larger version of this study.

• REC name

  North West - Haydock Research Ethics Committee

• REC reference

  11/NW/0551

• Date of REC Opinion

  28 Oct 2011

• REC opinion

  Further Information Favourable Opinion