Validation of the K-BILD questionnaire in CTD-ILD and SSc-ILD
Research type
Research Study
Full title
Validation of the Kings Brief Interstitial Lung Disease (K-BILD) Questionnaire in Connective Tissue Disease (CTD) associated and Systemic Sclerosis (SSc) associated Interstitial lung disease (ILD)
IRAS ID
336129
Contact name
Shaney Barratt
Contact email
Sponsor organisation
Research and Developent, North Bristol NHS Trust
Duration of Study in the UK
1 years, 9 months, 1 days
Research summary
Interstitial lung disease (ILD) is the leading cause of mortality in connective tissue disease associated lung disease, and can vary widely in severity from asymptomatic to life-threatening. Presently, the lack of a patient reported outcome (PROM) measure is an obstacle to drug development.
The Kings Brief Interstitial Lung Disease (K-BILD) questionnaire is a patient reported health status measure developed in 2012 and validated across a range of ILDs with concurrent validity against lung function and other health related quality of life questionnaires. It is not yet fully validated in a connective tissue disease associated ILD (CTD-ILD) population.
The principal aim of this project is to validate the psychometric properties of K-BILD in both CTD-ILD and Systemic sclerosis associated ILD (SSc-ILD) patients (the latter a specific subtype of CTD). More specifically, to demonstrate that the K-BILD correlates with existing non-disease specific PROMS, as well as with markers of lung disease severity.
Secondly we intend to demonstrate the short term repeatability of the K-BILD in stable non-progressive CTD-ILD and SSc-ILD patients, and also the discriminative validity of K-BILD using lung function, perceived health status and supplementary oxygen use as markers of disease severity.
This project will also assess the face and content validity of K-BILD in CTD-ILD and SSc-ILD patients ('relevance of the questionnaire to patients illness experience), and finally any correlation between patient coping strategies and symptom burden in CTD-ILD and SSc-ILD.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
24/WM/0048
Date of REC Opinion
20 May 2024
REC opinion
Further Information Favourable Opinion