Validation of Peptest for the detection of reflux in cough
Research type
Research Study
Full title
Validation of Peptest™ for the detection of reflux in cough: induced cough in normal volunteers.
IRAS ID
154889
Contact name
Alyn Morice
Contact email
Sponsor organisation
Hull and East Yorkshire Research and Development Department
Research summary
The detection of pepsin in the sputum, saliva or bronchial biopsy has been found to be an accurate marker of reflux into the airways. Pepsin is solely produced by parietal cells in the stomach. The presence of pepsin in the upper airways therefore indicates reflux. The Peptest™ lateral flow device has been shown to be effective in the detection of pepsin in sputum and saliva of patients with chronic cough and gastro-oesophageal reflux6. We have detected pepsin in expectorated saliva during episodes of cough, apparently supporting a diagnosis of airways reflux7. Critics, however, have suggested that the act coughing itself is responsible for the reflux.
This study aims to identify if cough induced by inhaled citric acid in healthy adult volunteers leads to detectable pepsin in expectorated saliva
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
14/YH/1026
Date of REC Opinion
16 Jul 2014
REC opinion
Further Information Favourable Opinion