Validation of OPTICS & H2FPEF scores for post-capillary PH
Research type
Research Study
Full title
Validation of the OPTICS and H2FPEF scores for the non-invasive prediction of post-capillary pulmonary hypertension.
IRAS ID
294965
Contact name
Martin Johnson
Contact email
Sponsor organisation
NHS National Waiting Times Centre
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Summary of Research
Pulmonary hypertension (PH) is a condition caused by high blood pressure within the blood vessels of the lungs. The treatment of PH is determined by its causes which can broadly be classified into post-capillary pulmonary hypertension and pre-capillary pulmonary hypertension. It is important to differentiate these two causes due to significant differences in their treatments.
The H2FPEF score and the OPTICS score are scoring systems that may aid clinicians in determining the probability of post-capillary PH at the time of referral to specialist units for pulmonary hypertension.
We intend to investigate the validity and utility of the H2FPEF and OPTICS score as tools to predict post-capillary pulmonary hypertension by applying these scores retrospectively to patients previously referred to a pulmonary hypertension unit and comparing the scores to the final diagnosis of pre- or post-capillary PH.
Summary of Results
The H2FPEF and OPTICS scores have been proposed as non-invasive scoring systems to predict postcapillary pulmonary hypertension (PH). This study used data collected in the past to evaluate these scores. It found that whilst the scores performed well, they were unable to perfectly exclude precapillary PH. This means if they were used in a clinical context, patients with precapillary pulmonary hypertension might be missed.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
21/ES/0078
Date of REC Opinion
15 Jul 2021
REC opinion
Favourable Opinion