Validation of molecular assay for foetal Rh D genotype
Research type
Research Study
Full title
Validation of assay for foetal Rh D genotype in antenatal patients
IRAS ID
195667
Contact name
Kieran Morris
Contact email
Sponsor organisation
Northern Ireland Blood Transfusion Service
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Women who are pregnant and have a blood group type Rh D negative have different antenatal care. They may be carrying a baby who is Rh D positive or Rh D negative. If the baby is Rh D positive there may be a leaking of blood from the baby's to the mother's circulation. This can give rise to the formation of a red cell antibody known as anti-D which can cause problems in the pregnancy and at delivery. This study is designed to predict the Rh D type of the baby from a maternal blood sample in early pregnancy. Identifying those babies who are Rh D negative, approximately 40% will mean a different antenatal care programme which will not require the administration of a blood product known as anti-D immunoglobulin to prevent the formation of red cell antibody.
REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
16/SW/0153
Date of REC Opinion
19 May 2016
REC opinion
Unfavourable Opinion