Validation of bioimpedance and NIRS in pulmonary hypertension
Research type
Research Study
Full title
Validation of bioimpedance estimates of cardiac output and near infrared spectroscopy estimates of muscle oxygen content in subjects suspected of having pulmonary hypertension
IRAS ID
163343
Contact name
Martin Johnson
Contact email
Sponsor organisation
NHS National Waiting Times Health Board
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
This study will enrol patients being assessed for pulmonary hypertension (PH), a condition in which there is increased pressure within the pulmonary arteries causing progressive right heart failure and ultimately death. Accurate noninvasive techniques to measure cardiac output and muscle oxygen content are of considerable value in these patients as they can prevent the need to perform and repeat right heart catheterisation procedures. Bioimpedance (impedance cardiography) is a noninvasive technique for estimating cardiac output which requires only the positioning of two electrodes on the chest wall. There are limited data available to define its accuracy in PH particularly in the lying position and during exercise. Near infrared spectroscopy (NIRS) is a technique which estimates oxygen content of peripheral muscles and requires the placement of two optodes on the thigh. Again there are limited data on its use in PH. The aim of this study is to compare these techniques against measurements taken during cardiac MRI and right heart catheterisation performed as part of the patient’s routine care. The investigations will be carried out at the Golden Jubilee National Hospital in Clydebank where the Scottish Pulmonary Vascular Unit is based.
REC name
West of Scotland REC 3
REC reference
14/WS/1112
Date of REC Opinion
31 Oct 2014
REC opinion
Further Information Favourable Opinion