Validation of beat-to-beat wavefront direction using omnipolar mapping
Research type
Research Study
Full title
Validation of beat-to-beat wavefront direction using omnipolar mapping in human atrial flutter. (ATrial flutter Omnipolar Mapping - ATOM)
IRAS ID
255860
Contact name
Phang Boon Lim
Contact email
Sponsor organisation
Imperial College NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 5 months, 1 days
Research summary
Atrial fibrillation and atrial flutter are abnormal heart rhythms that cause irregular heart beat and affect a significant portion of the population. These heart rhythms cause symptoms such as palpitations, fatigue and breathlessness, can cause strokes, and are a significant cause of morbidity. They are treated by heating and destroying abnormal electrical circuits in the heart with heat from radiofrequency energy.
Treatment for some of these rhythms rely on complex electrical maps of the chambers of the heart. These are created with the help of cardiac catheters (plastic tubes that have electrodes at the end and are inserted to the heart through the groin veins). The data then is analysed by a software and a 3D map of the heart is created. The size of the electrical signals collected with catheters depend on the direction of the flow of electricity inside the heart.
The Advisor™ HD mapping catheter, has an electrode grid that allows us to investigate the direction of the flow of electricity by looking for the largest possible signal size between a number of electrode pairs, with the help of computer software (omnipolar mapping).
We are seeking to validate omnipolar mapping in a well-described circuit within the heart (Atrial Flutter) and compare it with the gold standard of Local Activation Time (LAT) mapping during routine, clinically indicated procedures of Atrial Flutter ablation. A conventional, LAT map will be created during the procedure, prior to treatment, to guide the procedure. A repeat map will be performed after ablation during the procedure. We will export the map files for off-line analysis with the omnipolar software.REC name
London - Riverside Research Ethics Committee
REC reference
19/LO/1758
Date of REC Opinion
17 Jan 2020
REC opinion
Further Information Favourable Opinion