VALIANT 1.5
Research type
Research Study
Full title
Validation of novel markers of left ventricular dysfunction and investigation of their role in predicting outcomes in patients with severe aortic stenosis undergoing TAVI. (trans catheter aortic valve replacement).
IRAS ID
353530
Contact name
Daniel Obaid
Contact email
Sponsor organisation
Research and Development Department SBUHB
Duration of Study in the UK
1 years, 5 months, 30 days
Research summary
People with a severe aortic valve stenosis (tight) often feel breathless and tired. Many are treated with a keyhole valve procedure. Some people bounce back quickly after treatment; others don’t. We want to see if simple information already available from routine heart scans, plus two small blood tests and a short quality of life questionnaire, can help predict who will do well and who may need closer follow‑up.
The study has two parts. First, we will look back at information already collected in Swansea about people who had the keyhole procedure between 2018 and 2023. We will use their routine planning heart scans to calculate new “early warning” signals of heart pump strain and check how these related to their later health. Second, we will follow 150 new patients having the procedure. We will ask them to complete a short quality‑of‑life questionnaire, take a small blood sample at the time of their procedure and another at 6 weeks, and do an extra ultrasound scan at 6 weeks. We will also call them at 12 months to see how they are getting on.
We will not change anyone’s treatment. The CT scan used is the same as the usual planning scan done for clinical care. The ultrasound scan uses sound waves (no radiation). Blood sampling may cause brief discomfort or a small bruise.
By bringing together simple measures from routine scans and blood, we aim to give teams a clearer picture of recovery, support better‑timed care, and improve patients’ day‑to‑day wellbeing after treatment. This study will help significant proportion of patients for whom the decision about key hole procedure is challenging for clinicians given discrepancies in aortic valve area and pressure gradients across the valve, named as paradoxical aortic valve stenosis.REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
26/YH/0054
Date of REC Opinion
2 Mar 2026
REC opinion
Favourable Opinion