Utility of quantitative MR parameters in pituitary lesions

• Research type

  Research Study

• Full title

  Utility of quantitative MR parameters in predicting hormonal status and histopathological diagnosis of pituitary lesions

• IRAS ID

  236441

• Contact name

  Kanna Gnanalingham

• Contact email

  kanna.gnanalingham@srft.nhs.uk

• Sponsor organisation

  Salford Royal NHS Foundation Trust

• Duration of Study in the UK

  3 years, 0 months, 31 days

• Research summary

  The objective of this proposed study is to undertake a large single centre retrospective analysis of previously acquired clinical MR imaging in a cohort of: confirmed functional secretory adenomas (prolactinomas and growth hormone secreting adenomas); non-functional pituitary adenomas (NFPA;) and other pituitary lesions (eg meningioma) which were initially thought to represent pituitary adenoma. The aim of this analysis is to determine if quantitative differences in T1 signal intensity, T2 signal intensity, contrast enhancement, tumour size, and tumour invasion can be used to firstly predict the secretory status of pituitary adenomas, and secondly differentiate true pituitary adenomas from other pathologies (as identified on post-operative histological analysis).

• REC name

  East of England - Cambridge Central Research Ethics Committee

• REC reference

  17/EE/0488

• Date of REC Opinion

  12 Dec 2017

• REC opinion

  Favourable Opinion