UTERUS CONTRACTILITY. Version 1
Research type
Research Study
Full title
ACTIONS OF HORMONES & RELATED COMPOUNDS ON UTERUS MUSCLE CONTRACTILITY
IRAS ID
234112
Contact name
Matthew Hogg
Contact email
Clinicaltrials.gov Identifier
REC Reference: 18/YH/0050, IRAS ID: 234112
Duration of Study in the UK
2 years, 11 months, 26 days
Research summary
Broadly speaking we are studying how chemicals, molecules and cells in the uterus interact with each other. In particular, we are interested in the actions of chemicals which may form the basis for designing new and better treatments of disorders associated with disordered contractility of the uterus. These include drugs which inhibit uterus contractility (eg. for use in threatened preterm labour) or stimulate contractility (eg. required during induction of labour and/ or restoration of uterine tone after delivery of the baby). While some of this work can be carried out using experimental animals e.g. rats and mice or with special cells bought from companies and grown in pots, it is vital to be able to compare these results with specimens and clinical information collected from real patients – the way in which animals respond to drugs is not always the same as humans. We are, therefore, particularly interested in determining whether or not new treatments, designed using animals and special cells, really can work in humans, so as to predict their likely future clinical use. Similarly, we are interested in how naturally-occurring substances interact with the human uterus and change its ability to function. The research mostly involve measuring how the muscle of the uterus contracts or relaxes in response to these different chemicals and substances – this is carried out immediately or soon after receipt of a specimen of uterus muscle. In addition, it may be necessary to store small samples, so at a later date we can examine the mechanisms by which these changes in contractility occur, looking for the presence of specific proteins and RNA within the muscle that are involved in the mechanisms of action.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
18/YH/0050
Date of REC Opinion
23 Feb 2018
REC opinion
Further Information Favourable Opinion