Use of WBMRI to differentiate adrenal lesions and paragangliomas
Research type
Research Study
Full title
Optimising Whole Body Magnetic Resonance Imaging Sequences to differentiate adrenal lesions and paragangliomas
IRAS ID
272697
Contact name
Umasuthan Srirangalingam
Contact email
Sponsor organisation
University College Lonodon Hospitals
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
This project aims to use new research magnetic resonance imaging (MRI) sequences to address diagnostic difficulties when differentiating and risk stratifying adrenal lesions and paragangliomas
Adrenal nodules are often found incidentally- the majority of these are benign, however, a significant proportion will secrete excess amounts of adrenal hormones that can have a significant metabolic effect on the individual. Other adrenal lesions may be malignant. Paragangliomas are tumours of the ganglia, found from neck to pelvis, which may be linked to adrenal lesions, can produce hormones and can run in families.
In order to differentiate between benign and malignant, functioning and non-functioning lesions, several different imaging modalities are often required. Scanning can take substantial time, involves radiation and if associated with significant cost to the NHS.
We plan to compare standard imaging (including CT, MRI and functional imaging) with whole body MR sequences for adrenal lesions and paragangliomas to assess whether the MR sequences can provide additional information to improve diagnostic accuracy and risk stratification.
REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
20/WM/0226
Date of REC Opinion
25 Sep 2020
REC opinion
Further Information Favourable Opinion