Use of waste lipoaspirate tissue to investigate stem & stromal cells
Research type
Research Study
Full title
Use of waste lipoaspirate tissue to investigate adult adipose tissue derived stem, stromal and related cells from patient undergoing lipoaspiration surgery
IRAS ID
218920
Contact name
Andrew McCaskie
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and University of Cambridge
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
Lipoaspiration is a procedure where subcutaneous fat is broken down and removed under general anaesthetic to fill soft tissue defects in a variety of conditions e.g. reconstruction after breast cancer surgery. The lipoaspirate (i.e. the removed fat tissue) is normally used for fat grafting and the remainder is disposed of as waste tissue. We plan to use this waste material for research.
Our aim is to understand cells within the fat that have been identified as potentially useful for tissue repair and regeneration, by our laboratory research. The primary objective of this application is to obtain fat for this purpose that would otherwise be discarded and then isolate cells from the fat, particularly adult stem and stromal cells. We have a specific interest in musculoskeletal repair, for instance joint cartilage. Following isolation our experiments will involve growing cells in culture, identification of markers on the surface, and single cell analysis. We hope that this will help identify cells and mechanisms that can be use in human therapy cartilage repair.REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
17/LO/0519
Date of REC Opinion
28 Apr 2017
REC opinion
Further Information Favourable Opinion