Use of Fluorescent Imaging Device (Moleculight) in Orthopaedic Surgery
Research type
Research Study
Full title
Use of Fluorescent Imaging Device (Moleculight) in Tissue Sampling, Biopsy & Debridement in Periprosthetic Joint Infection: A Feasibility Study
IRAS ID
293391
Contact name
Jonathan Stevenson
Contact email
Sponsor organisation
Royal Orthopaedic Hospital NHS FT
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Use of FLuorescent ImAging Device (Moleculight) in Tissue Sampling, Biopsy & Debridement in PeriproStHetic Joint Infection (FLASH): A Feasibility Study
Periprosthetic joint infection (PJI) is known to cause significant morbidity and mortality. The management of PJI includes irrigation and debridement of infected tissues. However, there is currently no objective way to identify and sample infected tissues in real-time intraoperatively. We are aiming to assess the effectiveness of a novel point-of-care fluorescent imaging device (Moleculight) in guiding tissue sampling and debridement to aid the diagnosis and eradication of periprosthetic joint infection (PJI) in surgery.
Consecutive case series (feasibility study) at The Royal Orthopaedic Hospital NHS Trust. We aim to enrol 5-10 patients into this study who have signed a consent form to participate in this project. The patients will undergo routine debridement and sampling procedures as per current guidelines, followed by the use of fluorescent imaging to detect any “missed” infected tissues. The additional samples taken with the guidance of fluorescent imaging are labelled and sent to the laboratory. The microbiology results from the additional tissues detected by Moleculight are analysed to assess the effectiveness and sensitivity of the device in detecting possible residual infected tissues. All other aspects of care will be according to the standard practice.
Outcome
• To confirm the effectiveness of real-time monitoring for the adequacy of mechanical debridement and tissue sampling in prosthetic joint infection surgery.
• To assess the ability of a fluorescent imaging device to detect areas of high bacterial burden for targeting sampling for speciation and antibiotic sensitivities.REC name
North West - Preston Research Ethics Committee
REC reference
22/NW/0345
Date of REC Opinion
29 Nov 2022
REC opinion
Further Information Favourable Opinion