Use of EBUS biopsy samples for cell culture in lung cancer/lymphoma
Research type
Research Study
Full title
Use of EBUS biopsy samples for cell culture in lung cancer/lymphoma
IRAS ID
154489
Contact name
Dipak Mukherjee
Contact email
Sponsor organisation
Basildon and Thurrock University Hospitals NHS FT
Duration of Study in the UK
0 years, 6 months, 27 days
Research summary
Obtaining adequate pathological specimen is essential in the diagnosis of cancer. Ultrasound guided sampling through airway (EBUSTBNA) has emerged as a safe and accurate technique in the diagnosis and staging of lung cancer (R1)but subtyping and/or genotyping of TBNA samples obtained by convex probe EBUS has long been considered to be limited by the lack of tissue architecture in these small tissue samples. The performance of small tissue samples in NSCLC subtyping has been proven to be accurate in modern pathology practice adopting cell blocks and immunohistochemistry (IHC), reducing the NSCLC not otherwise specified rate for needle aspiration samples to 8–23%. It has also shown recently a promising result in work up of mediastinal lymphadenopathy when lymphoma is suspected.
It is thought that at times EBUS TBNA sample is still inadequate for further essential testing for diagnostic and therapeutic purpose and enhancing the yield is possibly by cell culture will not only be useful for diagnosing lung cancer and lymphoma but also will provide material for future research study.
We have therefore developed a research proposal in collaboration with scientists at the biomedical research laboratory at Imperial College London, who have excellent record in basic scientific research and currently involved in similar research on cell culture for other type of diseases.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
14/EM/1273
Date of REC Opinion
25 Nov 2014
REC opinion
Favourable Opinion