Use of DGEMRIC to assess shoulder cartilage - pilot study.
Research type
Research Study
Full title
Use of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (DGEMRIC) to assess glenohumeral joint articular cartilage after shoulder dislocation - pilot study.
IRAS ID
135825
Contact name
Paul Robinson
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 9 months, 31 days
Research summary
This is a pilot study of 12 patients who have suffered a shoulder dislocation and choose to undergo either operative or non-operative treatment of the shoulder dislocation. The project will use delayed gadolinium-enhanced magnetic resonance imaging of cartilage (DGEMRIC) to assess the molecular properties of glenohumeral (shoulder joint) cartilage after shoulder dislocation. Currently, the molecular effects of shoulder dislocation on shoulder joint cartilage are unknown and have not previously been studied. It is important that we understand this area as there is a recognised incidence of cartilage injury in the shoulder related to shoulder dislocations. Using DGEMRIC we will assess the glycosaminoglycan (GAG) content of cartilage in the shoulder. Each participant will undergo two scans, the first scan after the initial dislocation and the second scan 6 months after undergoing operative stabilisation of the shoulder or 6 months of non-operative treatment. The participants will receive the standard treatment for shoulder dislocations.
REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
14/SW/1096
Date of REC Opinion
12 Nov 2014
REC opinion
Further Information Favourable Opinion