Urine Ngal as a Marker of Renal Dysfunction in Type 2 Diabetes
Research type
Research Study
Full title
Urine NGAL as a Marker of Renal Dysfunction in Type 2 Diabetes
IRAS ID
147743
Contact name
Shirley Sharland
Contact email
Sponsor organisation
Aneurin Bevan University Health Board
Research summary
Diabetic Kidney Disease (DKD) or diabetic nephropathy is widely recognised as a complication in Type 2 Diabetes Mellitus (T2DM). Approximately 1 in 6 T2DM patients will develop DKD progressing to end stage renal disease (ESRD).Diagnosis and management of renal disease currently uses serum creatinine and urine microalbumin. T2DM patients have these investigations performed routinely as part of their care. Urine microalbumin is used to assess the degree of nephropathy and increased levels or macroproteinuria indicates the need for medical intervention to minimise further deterioration of renal function. Renal functional reserve is such that a loss of >75% functioning nephrons is possible before an abnormal serum creatinine is observed. Production of creatinine is also influenced by factors such as body muscle mass and exercise. It has been long recognised as a poor marker of renal function and normal results may mask a significant deterioration in renal function. The usefulness of this assay is limited to monitoring serial measurements to identify rates of change. A more reliable laboratory assay both specific and sensitive enough to adequately detect deterioration in renal function is needed.
Urine Neutrophil Gelatinase Associated Lipocalin (NGAL) is a new marker or test of renal function and is increased at an earlier time interval than serum creatinine. Its usefulness has been focussed in Acute Kidney Injury (AKI) as increased levels are detected much earlier than serum creatinine. This study aims to identify the potential of this marker as an earlier indicator of renal dysfunction in Chronic
Renal Failure (CRF) which can occur in T2DM. Also, the relationship between urine Ngal and microalbumin levels will be investigated.REC name
West of Scotland REC 4
REC reference
14/WS/1062
Date of REC Opinion
22 Sep 2014
REC opinion
Further Information Favourable Opinion