Urinary micronutrient profile in different renal conditions
Research type
Research Study
Full title
A prospective observational study to investigate urinary micronutrient profile in patients with different renal conditions
IRAS ID
207571
Contact name
Mark Devonald
Contact email
Sponsor organisation
Nottingham University Hospitals NHS Trust
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
Acute kidney injury (AKI) is the rapid deterioration in kidney function over hours or days. It is a common problem that is associated with significant morbidity and mortality and affects approximately 10-20% of hospital admissions.
AKI is currently identified using blood tests (creatinine levels) and urine output. Both of these are delayed markers of AKI. There is an urgent need for a reliable early test (biomarker) to allow earlier detection of AKI. In research using pigs to study AKI, we have identified that the urinary micronutrient profile (including amino acids, vitamins and trace elements) may have a role as a novel early biomarker of AKI. we are currently studying the changes in urine micronutrient profile in different groups of patients with AKI.
It is important for us to know whether any other kidney conditions would change the micronutrient profile in the absence of AKI. This study will measure these biomarkers in patients with some of these kidney conditions: specifically urine infections (UTI), protein in the urine, chronic kidney disease, and the commonest types of kidney cancer.
This study involves analysing urine samples from adult patients in the outpatient clinic setting (new patient renal clinics, chronic kidney disease clinics and urology cancer clinics) and during attendance for renal biopsies. We will ask volunteers to provide two urine samples at different times. It is standard practice for patients at these clinics to have blood tests.
We will measure urinary micronutrient profile in these populations and review routine blood tests to ensure the patients qualify as a control group.
REC name
London - Brent Research Ethics Committee
REC reference
16/LO/1201
Date of REC Opinion
30 Jun 2016
REC opinion
Favourable Opinion