Urinary micronutrient profile as AKI biomarker after cardiac surgery
Research type
Research Study
Full title
Urinary micronutrient profile as an early biomarker of acute kidney injury following cardiac surgery
IRAS ID
190348
Contact name
Mark Devonald
Contact email
Sponsor organisation
Nottingham University Hospitals NHS Trust
Duration of Study in the UK
2 years, 6 months, 2 days
Research summary
Acute kidney injury (AKI) is the rapid deterioration in kidney function over hours or days. It is a common problem that is associated with significant morbidity and mortality and affects approximately 10-20% hospital admissions.
AKI is currently identified using blood tests (serum creatinine levels) and urine output. Both of these are delayed markers of AKI. There is an urgent need for a reliable early test (biomarker), to allow earlier detection of AKI. In research using pigs to study AKI we have identified that urinary micronutrient profile (including amino acids, vitamins and trace elements) may have a role as a novel early biomarker of AKI. This study will investigate whether this biomarker predicts the development of Aki and how serious it is.
This study involves analysing urine samples from adult patients who have been admitted for heart surgery. This group of patients are recognised to be at relatively high risk of developing AKI. It is an observational study so will not require any intervention or deviation from standard care. It is standard practice for patients to have a urinary catheter placed for monitoring after their heart surgery. We will take samples from the catheter every hour for four hours after the operation, and measure the hourly urine output. We will review routine daily blood tests (serum creatinine) for the duration of the admission (or for 5 days and then again on discharge) to identify cases where AKI occurs. Follow up blood tests will be taken 30 days after the operation. Exceptionally an additional blood test may be required if blood tests are not measured daily, and these will be taken according to Trust guidelines.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
15/EM/0451
Date of REC Opinion
28 Sep 2015
REC opinion
Favourable Opinion