Urinary Metanephrine/Creatinine Ratio on Early Morning Random Sample
Research type
Research Study
Full title
Can an Early Morning Random Sample Collection for Urinary Metanephrine/Creatinine Ratio replace a 24 hour urine collection measured by chromsystems HPLC?
IRAS ID
140628
Contact name
Julia Dickinson
Contact email
Sponsor organisation
Manchester Metropolitan University
Research summary
Pheochromocytoma is a rare adrenal gland tumourThe tumour sporadically secretes catecholamine’s which increases hypertension. Approximately <0.2% of all patients with hypertension have an associated adrenal cancer.Current protocol at York NHS Teaching Hospital dictates that a 24 hour urine collection should be collected to maximise the chance of identifying a positive result. However 24 hour urinary collections are frequently poorly performed and can give rises into over or underestimation of actual metanephrine concentration. Also this technique has limited practical applications for collecting urine on small children.
A logical approach is to measure an early morning collection. This reduces the affect of diurnal variation and limits the sporadic increases in normal catecholamine production.
Therefore my project Hypothesis is:
The expected outcomes for this project are to prove that early morning metanephrine-creatinine ratio is a better diagnostic marker for Pheochromocytoma than a 24 hour sample collection.
The aims of the study will therefore be;
1) Assess if the random urine metanephrine correlates to the current 24 hour collection method.
2) Assess the significance of creatinine ratios in both random and 24 hour collections.
3) Develop a reference range.
4) Determine if an early morning (overnight) random urine collection can positively identify the presence of a Pheochromocytoma (Dependant on positive sample collections).REC name
North West - Liverpool Central Research Ethics Committee
REC reference
13/NW/0834
Date of REC Opinion
25 Nov 2013
REC opinion
Favourable Opinion