UPLift-X Trial
Research type
Research Study
Full title
UpLift-X Trial 1: A cluster factorial randomised controlled trial of digitally-enabled group psychotherapy for common mental disorders
IRAS ID
340528
Contact name
Jaime Delgadillo
Contact email
Sponsor organisation
Rotherham Doncaster and South Humber NHS Foundation Trust
Duration of Study in the UK
1 years, 6 months, 7 days
Research summary
Mental health problems are common and affect around one in six adults. Most countries lack sufficient mental health provision to meet the needs of people with common mental disorders (CMD). Four developments in the psychotherapy field have the potential to address the shortfalls in access and effectiveness of treatment; 1) efficient group-based psychological therapy, 2) effective ‘transdiagnostic’ interventions relevant for a wide variety of CMDs, 3) accessible internet-delivered digital psychological interventions and 4) personalised treatment tailored for each patient. UpLift-X is a research programme than aims to integrate all these four advances into a single and comprehensive digital health platform, which we expect will be a cost-effective solution to maximize access to highly effective treatment for a large population of patients with CMDs. The overall aim of this study is to test the effectiveness of a modularised, transdiagnostic, digitally-enabled 12-session group intervention for the treatment of CMD, based on the Unified Protocol (UP) for the treatment of emotional disorders. The therapy will be accessed on a digital platform which will include helpful videos and information about coping skills. Funded by Innovate UK, a pragmatic, multi-site, factorial cluster randomised controlled trial will recruit patients accessing NHS Talking Therapies treatment for CMDs. The trial will evaluate if altering the sequence of UP therapy modules affects clinical outcomes or drop-out and aim to develop a personalised module selection method to tailor treatment to the needs of patients with a wide range of clinical problems. The study will also evaluate the clinical and cost-effectiveness of digitally-enabled group therapy compared to individual Cognitive Behavioural Therapy (current standard treatment).
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
24/YH/0182
Date of REC Opinion
11 Oct 2024
REC opinion
Further Information Favourable Opinion