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Research type
Research Study
Full title
The effects of reducing prolonged sitting bouts with regular light upright movement breaks on glucose regulation in individuals at high risk of or with type 2 diabetes
IRAS ID
232310
Contact name
Michelle Muessel
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
1 years, 8 months, 1 days
Research summary
Research Summary:
This study aims to show how breaking up prolonged sitting time with light upright movement affects glucose regulation, as well as other important metabolic biomarkers such as insulin and triglycerides, over a four-six week period. The study will consist of behavioural intervention, with pre- and post-intervention measurement phases being controlled in the laboratory with two different measurement conditions (A: sitting for 7.5 hours, B: breaking up sitting time with light upright movement for 5 minutes every 30 minutes). The study is exected to last aroud 60 days per partiicpant.
This is being studied as current evidence suggests breaking up prolonged sitting over the course of a day has a beneficial effect on glucose regulations and responses to meals, but the effect over a longer period (i.e. 4-5 weeks) is not known. Improving glucose regulation plays a large role in the prevention of type 2 diabetes, as well as a number of associated health issues. This study looks to recruit those identified as high risk of developing type 2 diabetes or those with diet controlled type 2 diabetes, as this patient group are the most likely to benefit from new interventions to better regulate glucose.
This is being studied as current evidence suggests breaking up prolonged sitting over the course of a day has a beneficial effect on glucose regulations and responses to meals, but the effect over a longer period (i.e. 4-5 weeks) is not known. Improving glucose regulation plays a large role in the prevention of type 2 diabetes, as well as a number of associated health issues. This study looks to recruit those identified as high risk of developing type 2 diabetes, as this patient group are the most likely to benefit from new interventions to better regulate blood glucose.Summary of Results:
50 participants enrolled in the study, 33 completed and 15 were identified as being compliant to the intervention. The intervention did not change prolonged sitting, however there was an improvement on total volume and intensity of physical activity. Postprandial glucose, insulin and triglyceride to breaking prolonged sitting were maintained following an intervention designed to reduce prolonged sitting in free-living conditions. Future research needs to focus on improving the effectiveness of interventions designed to reduce sedentary behaviour.REC name
East Midlands - Derby Research Ethics Committee
REC reference
18/EM/0006
Date of REC Opinion
31 Jan 2018
REC opinion
Further Information Favourable Opinion