UNICORNS: Uveitis in childhood
Research type
Research Study
Full title
UNICORNS: Uveitis in childhood prospective national cohort study
IRAS ID
258638
Contact name
Ameenat Lola Solebo
Contact email
Sponsor organisation
UCL ICH GOS / GOSH joint R&D office
Duration of Study in the UK
4 years, 0 months, 30 days
Research summary
Childhood uveitis (inflammation inside the eye) is an uncommon disorder which carries the risk of blindness. Inadequate treatment of active inflammation has been shown to be related to poor outcome. There has been no population based, prospective longitudinal study of all cause childhood uveitis, with resultant limitations in the evidence base used to counsel affected families, balance treatment decisions, or plan further research. The aim of our proposed study is to describe the characteristics of childhood onset uveitis (onset when aged under 18 years) and describe outcomes. We shall also aim to identify the socio-demographic, clinical, biological and treatment related determinants of outcome. Early (1-2 years following diagnosis) outcomes will be described in the first instance: however, through the creation of a national inception cohort, we shall enable longer term studies of outcome for affected children and families. There will be no change to routine clinical care.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
20/LO/0661
Date of REC Opinion
1 Jul 2020
REC opinion
Further Information Favourable Opinion