Understanding medication adherence in chronic Type B dissection
Research type
Research Study
Full title
Understanding anti-hypertensive medication adherence in chronic Type B aortic dissection and its association with disease progression
IRAS ID
198364
Contact name
Ruth Nicholson
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
Aortic dissection occurs when there is a tear in the wall of the aorta causing blood to flow between the layers of the vessel wall; is an important disease process in vascular surgery. The majority of patients are managed conservatively, however it is associated with significant morbidity and mortality with over half of patients requiring some form of surgical intervention within 5 years of presentation. Around 80% of patients presenting with aortic dissection have uncontrolled hypertension and strict blood pressure control is the mainstay of conservative treatment. Whilst there has been no dedicated work looking at adherence with anti-hypertensive medication adherence in the dissection population, in the wider hypertensive population it is a significant problem with around 50% of patients with hypertension not fully adherent with their medication. The aim of this study is to adopt a cross-sectional questionnaire based approach to assess adherence to anti-hypertensive medication in patients with chronic type B aortic dissection, understand detailed reasons for poor adherence, describe any associations between disease progression and medication non-adherence and identify potential interventions and strategies based around behavioural insight theory to improve medication adherence and reduce aortic morbidity in this population.
REC name
West of Scotland REC 1
REC reference
16/WS/0018
Date of REC Opinion
19 Jan 2016
REC opinion
Favourable Opinion