Understanding Intestinal Fibrosis
Research type
Research Study
Full title
Collection of intestinal and colon tissues for research purposes
IRAS ID
290079
Contact name
Selim Cellek
Contact email
Sponsor organisation
Anglia Ruskin University
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Abdominal adhesions are the cause of most common complications following intra-abdominal surgery which usually requires re-operations. Currently there are no medicines to prevent adhesions. The adhesions are caused by a pathological process called fibrosis which is essentially uncontrolled wound healing. The main cells that are responsible for fibrosis is called myofibroblasts. How the myofibroblasts contribute to adhesions is poorly understood. Our aim will be to isolate these cells from human intestine and colon tissue and investigate them outside the body with the ultimate aim of finding new medicines to prevent and treat adhesions. The tissue which will otherwise be discarded will be collected from the operating theatre at Portsmouth Hospital and will be transported to our research labs in Anglia Ruskin University, Chelmsford immediately in ice. The cells will be isolated from the tissue and their function will be investigated in the lab. No DNA or genetic analysis will be performed. The tissue samples will be destroyed by incineration at the end of the study. The samples will be totally anonymised.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
21/PR/0165
Date of REC Opinion
11 Mar 2021
REC opinion
Favourable Opinion