Understanding impaired cognition in Neuro-degenerative diseases
Research type
Research Study
Full title
Understanding cognitive and sensory impairment in patients with Neuro-degenerative diseases
IRAS ID
279309
Contact name
Qadeer Arshad
Contact email
Sponsor organisation
University of Leicester
Clinicaltrials.gov Identifier
https://osf.io/hbxvk/, OSF Pre-registration link
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
This study aims to investigate how sensory and cognitive function is impaired in different neuro-degenerative diseases such as dementia, map this function in different neuro-degenerative diseases, and explore possible mechanisms. The rationale is provided by previous research which shows some cognitive and sensory functions (such as reading, sensitivity to contrast and motion) are impaired in neurodegenerative diseases including Alzheimer’s disease (Arnaoutoglou et al, 2017; Glosser et al, 2002; Salobrar-Garcia et al, 2015; Velarde et al, 2012) and Posterior Cortical Atrophy (See Caine, 2004 for a review). The proposed study aims to understand:
i) Which sensory and cognitive functions are affected in different neurodegenerative diseases,
ii) How (i.e. possible mechanisms) these deficits may occur, and
iii) How this may differ from normal ageing in people with neurodegenerative diseases.
It is hoped this research will improve understanding of cognitive and sensory function in patients with different neurodegenerative diseases, which may assist diagnoses and help improve quality of life (Lawrence et al, 2009). The proposed study is a cross-sectional observational study that will recruit patients with neurodegenerative disorders from memory, balance and neurology clinics at NHS hospitals, and by advertising the study on Join Dementia Research and at community support groups. Participants will complete cognitive and sensory function tests including computerised experiments, and clinical tests. Funding is from Alzheimer’s Society Dunhill Trust, ESRC and Leverhulme Trust.REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
21/EM/0017
Date of REC Opinion
8 Feb 2021
REC opinion
Further Information Favourable Opinion