Understanding healthy microbiota in aged skin
Research type
Research Study
Full title
Understanding healthy microbiota in aged skin
IRAS ID
306110
Contact name
Matthew Hardman
Contact email
Sponsor organisation
University of Hull
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The skin is the body's largest organ and provide niches for a wide range of microorganisms, which have important roles in protection and inflammatory responses. Many factors can influence the diversity and composition of this ecosystem (known as microbiome). Recently, some studies have been showing that ageing process is accompanied by changes in bacterial composition. However, it is still not clear the cause-effect relationship and how this can actually impact skin homeostasis. Therefore, this study aims to investigate and provide more information regarding the cross-talk between microbiome profiles and skin parameters in human skin, and evaluate if potential microbial differences are related to skin ageing. Analysis of skin parameters using a multi probe device will be performed to access ageing indicators, such as sebum content, elasticity, wrinkles and hydration. Swab samples and micro biopsies will be collected from consenting healthy adult volunteers from 3 different groups (young - 18-29, middle-age - 30-59 and elderly - 60+). These samples will be used to investigate skin morphology, bacterial diversity, as well as the role of bacterial mechanisms in the ageing process.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
22/NE/0018
Date of REC Opinion
15 Feb 2022
REC opinion
Further Information Favourable Opinion