Understanding emotional distress in people with ocular tumours:
Research type
Research Study
Full title
Understanding emotional distress in people with ocular tumours:ED-POT
IRAS ID
268387
Contact name
Peter Fisher
Contact email
Sponsor organisation
University of Liverpool
Duration of Study in the UK
5 years, 4 months, 1 days
Research summary
Liverpool Ocular Oncology Centre (LOOC) at the Royal Liverpool & Broadgreen University Hospitals Trust (RLBUHT) is a supra-regional tertiary referral centre for the treatment of adult ocular tumours in England.
Clinical evaluation in ocular oncology involves assessment of visual acuity, local tumour control and disease-free survival but does not assess the person’s experience of treatment (Hope-Stone et al 2016)
Studies have investigated the role of different treatments and prognostic related factors on patient reported outcomes including psychological outcomes, mood, general and ophthalmological related quality of life, and worry about recurrence and have provided insight into potential risk factors for psychological morbidity. These studies have helped clinicians inform patients of the likely clinical and psychological outcomes patients can expect following treatment for uveal melanoma (Damato et al. 2018; Frenkel et al. 2018; Miniati et al. 2017 Brown et al 2018) However, as far as we are aware, no previous studies have investigated modifiable psychological processes that could alleviate emotional distress in patients with uveal melanoma, or other ocular tumours. It is important to investigate such processes as, although distress after a diagnosis of cancer is normal and often diminishes naturally over time (Cook et al. 2015a), around one third of cancer patients will experience persistent emotional distress.
This study aims to better understand the psychological processes that underpin emotional distress (anxiety & depression) in patients with ocular tumours after accounting for ophthalmological, treatment and prognostic related factors.This will guide development of psychological interventions for patients experiencing persistent distress.
All adult patients attending LOOC over a 3 year period diagnosed with an ocular tumour will be invited to participate. Those consenting to participate will be asked to complete and return (online or on paper) a set of questionnaires at 4 weeks, 3, 6,12 and 24 months following diagnosis.References
Brown SL, Hope-Stone L, Heimann H, Salmon. P.(2018) Predictors of anxiety and depression two years following treatment in uveal melanoma survivors. Psycho-oncology. 27 1727-1734.Cook, S. A., Salmon, P., Dunn, G., Holcombe, C., Cornford, P., & Fisher, P. (2015a). A prospective study of the association of metacognitive beliefs and processes with persistent emotional distress after diagnosis of cancer. Cognitive Therapy and Research, 39(1), 51-60.
Damato, B., Hope-Stone, L., Cooper, B., Brown, S. L., Salmon, P., Heimann, H., & Dunn, L. B. (2018). Patient-reported Outcomes and Quality of Life After Treatment of Choroidal Melanoma: A Comparison of Enucleation Versus Radiotherapy in 1596 Patients. American Journal of Ophthalmology, 193, 230-251.
Frenkel, S., Rosenne, H., Briscoe, D., Hendler, K., Bereket, R., Molcho, M., & Pe'er, J. (2018). Long‐term uveal melanoma survivors: measuring their quality of life. Acta Ophthalmologica, 96(4), e421-e426.
Hope-Stone, L., Brown, SL. Heimann, H., Damato, B., & Salmon, P.( 2016) Two-year patient-reported outcomes following treatment of uveal melanoma. Eye 30: 1598-1605
Miniati, M., Fabrini, M. G., Genovesi Ebert, F., Mancino, M., Maglio, A., Massimetti, G., ... & Marazziti, D. (2018). Quality of Life, Depression, and Anxiety in Patients with Uveal Melanoma: A Review. Journal of Oncology,1-10
REC name
East of Scotland Research Ethics Service REC 1
REC reference
19/ES/0135
Date of REC Opinion
4 Nov 2019
REC opinion
Further Information Favourable Opinion