Under and Over
Research type
Research Study
Full title
Under & Over: A controlled study to develop an upper limb rehabilitation tool for people with Multiple sclerosis.
IRAS ID
285101
Contact name
Gavin Giovannoni
Contact email
Sponsor organisation
Queen Mary University of London
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 6 months, 30 days
Research summary
Multiple Sclerosis (MS) is a progressive neurological condition of the central nervous system for which there is no cure. Symptoms include motor and sensory dysfunction, bladder and bowel dysfunction as well as speech and swallowing difficulties. It commonly leads to cumulative, mixed disabilities over time. The combination of different symptoms and disabilities often limits a person’s ability to perform activities of daily living and to actively participate in social and occupational activities which then impacts on their quality of life.\n \nThe two main strategies for managing MS symptoms include, medication and rehabilitation. However, historically treatment strategies have focused predominantly on preserving lower limb function thus strategies to improve upper limb function is often neglected. The importance of maintaining upper limb (hand and arm) function is significant for people who have already lost lower limb function. Further loss of functioning contributes to low mood, reduced independence and quality of life. \n \nThis study aims to research how an engaging everyday activity, Under & Over, can become a rehabilitation tool to improve upper limb function in people with MS. The study will use a randomised wait list control group design, meaning that participants will be randomised to either the immediate rehabilitation group or the wait list group. Each group will perform the Under & Over task for 12 weeks, following a predetermined programme of instructions. Participants will complete a number of baseline measures measuring their current upper limb function, their quality of life and level of fatigue. This will happen at the start of the study, after 12 weeks of rehabilitation activity and again at a 12 week follow up.\n\nParticipants will access study information through the study website. This will provide the consenting procedure, study information, record participants responses and support (anonymised) participant interaction. \n \n\n
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
20/YH/0259
Date of REC Opinion
26 Oct 2020
REC opinion
Further Information Favourable Opinion