UMOD NKCC2 interaction on salt-sensitivity in hypertension
Research type
Research Study
Full title
Clinical Study of UMOD NKCC2 interaction on salt-sensitivity in hypertension
IRAS ID
202760
Contact name
Sandosh Padmanabhan
Contact email
Sponsor organisation
Clinical Research and Development, NHS Greater Glasgow and Clyde
Duration of Study in the UK
3 years, 6 months, 2 days
Research summary
High blood pressure is the leading risk factor for the development of cardiovascular disease, heart attack and stroke. Half of people with high blood pressure are uncontrolled and they have a 7-fold increased cardiovascular risk. Current treatment for high blood pressure is with a combination of different drugs from differing drug classes. Drugs are chosen based upon the age and ethnicity of the patient however not all patients respond to all drugs. There is emerging evidence that variations in a gene (Uromodulin) may affect how some patients respond to a specific drug used to treat high blood pressure (loop diuretic). Genes carry the information that determines your traits which are features or characteristics that are passed on to you — or inherited — from your parents.
This study aims to determine if individuals who possess different variations in the Uromodulin gene have a better blood pressure response to loop diuretics than those who do not possess the genetic variant. This will enhance our understanding of the mechanistic basis of blood pressure regulation and provide valuable insights that will direct future clinical trials and treatment guidelines.
Participants will be asked to give a saliva sample that can be tested to determine if they possess the genetic variant or not. All participants will then be given a course of drug (loop diuretic) for 16 weeks and have their blood pressure regularly measured. At the end of the study the changes in blood pressure between the two groups will be compared.
REC name
West of Scotland REC 5
REC reference
16/WS/0160
Date of REC Opinion
23 Aug 2016
REC opinion
Favourable Opinion