UKR ForceS 1.0
Research type
Research Study
Full title
Oxford Unicompartmental Knee Replacement ForceS - a cadaveric study
IRAS ID
249693
Contact name
Andrew Price
Contact email
Sponsor organisation
University of Oxford / Clinical Trials and Research Governance
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
The Oxford medial unicompartmental knee replacement (OUKR) is a recognised surgical treatment for end stage osteoarthritis of the knee. For the OUKR to be used it is a requirement that the ligaments of the knee are intact, and remain so after surgery. \n\nAt present implantation of the OUKR involves the use of feeler gauges, with the surgeon determining the optimum balance based on the ease of fit of these gauges, to reflect tension in the soft tissues. This however is a subjective assessment, and it is unclear whether different surgeons achieve the same balance. There now exist sensors that can objectively measure the forces applied whilst balancing the knee. \n\nIn this pilot experimental study we therefore aim to determine:\n(1) the force applied across the medial knee after OUKR and \n(2) the consequences on forces applied across the medial knee of component mis-sizing after OUKR\n\nTo achieve objective (1) we will implant the OUKR using the standard technique in cadaveric lower limbs (limbs obtained from individuals who have donated their bodies to education and research after death) in a lab setting. We will then use sensors specifically designed to measure the compressive force across the medial compartment of the knee after OUKR. Forces will be measured in the standard positions of a flexed and extended knee. In addition we will measure the force across the medial compartment of the knee when moving the knee through a range of motion from full extension to full flexion.\n\nTo achieve objective (2) we will intentionally upsize and downsize components (bearing and femoral component) from the appropriate size. We will then assess forces across the medial compartment through the medial side of the knee as in objective (1).
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
19/YH/0233
Date of REC Opinion
5 Jul 2019
REC opinion
Favourable Opinion