UK Prospective Diabetes Study (UKPDS) Legacy Study

• Research type

  Research Study

• Full title

  UK Prospective Diabetes Study (UKPDS) Legacy Study: long term follow-up of participants into electronic health records

• IRAS ID

  249166

• Contact name

  Rury R. Holman

• Contact email

  rury.holman@dtu.ox.ac.uk

• Sponsor organisation

  University of Oxford / Clinical Trials and Research Governance

• Duration of Study in the UK

  5 years, 0 months, 1 days

• Research summary

  Did the different levels of blood glucose or blood pressure lowering among participants in the UKPDS affect their long-term (up to 40 years) risk of dementia, death or other major diseases (e.g. heart attacks, strokes and kidney disease)?

  The United Kingdom Prospective Diabetes Study (UKPDS) which ran from 1977 - 1997 asked simple questions:
  • Can the risk of complications in type 2 diabetes be reduced by intensive blood glucose control?
  • In patients with type 2 diabetes and high blood pressure, can the risk of complications be reduced by tight control of blood pressure?
  • Does any specific treatment for type 2 diabetes or for high blood pressure confer any particular benefit?

  The study was extremely successful and demonstrated that important complications of type 2 diabetes can be prevented by:
  • Better blood glucose control than that usually achieved, using existing treatments
  • Better blood pressure control than that usually achieved, using existing treatments

  As dementia is now affecting so many people, researchers now wish to look at UKPDS participants' study records and electronic medical records to study the effect of blood pressure lowering and improved glucose control on reducing the risk of developing dementia later in life. At the same time they will take the opportunity to look at the effect of blood pressure lowering and improved glucose control on reducing the long-term risk of death, other important diseases (e.g. heart attacks, strokes and kidney disease)and healthcare use in the UK.

• REC name

  South East Scotland REC 01

• REC reference

  18/SS/0127

• Date of REC Opinion

  10 Oct 2018

• REC opinion

  Favourable Opinion