UK CLL Biobank

• Research type

  Research Tissue Bank

• IRAS ID

  269007

• Research summary

  UK CLL Biobank

• REC name

  North West - Haydock Research Ethics Committee

• REC reference

  19/NW/0573

• Date of REC Opinion

  18 Sep 2019

• REC opinion

  Favourable Opinion

• Data collection arrangements

  All patients entering CLL clinical studies (that the UK CLL Biobank is part of) will be asked if they would like to give samples to the Biobank by their local healthcare team. Samples before treatment and at further timepoints when
  appointments are scheduled as part of the clinical study will be collected (samples are not mandatory, and all do not have to be given but enhances the value of the trial). Before treatment the samples collected are a blood sample (clotted & unclotted), saliva and if being done a small amount of liquid bone marrow for some trials. The samples are then sent to the central labs at the University of Liverpool where it is processed to separate out the white cells from the blood and bone marrow. Non tumour DNA is isolated from the saliva, serum from the clotted blood and plasma from the unclotted blood. Sample storage and processing all takes place within a special facility that is dedicated to only
  handling samples from clinical trials (GCPLab facility), as there are government regulations that need to be adhered to.
  The data that is stored and released to researchers by the biobank is the clinical study and the clinical study number. The consent form that is signed and a copy sent to the biobank is retained in a safe and only acknowledgment that it has been received is stored on any database.

• Research programme

  The UK CLL Biobank is of pivotal importance to the NCRI CLL trials portfolio as it allows the collection and storage of clinical samples to the highest standards across multiple trials. In doing so, the Biobank provides the UK with an unrivalled resource for high quality biomarker research which will ultimately lead to the application of stratified medicine to CLL therapy.

• Storage license

  12020

• RTBTitle

  UK CLL Biobank

• Establishment organisation

  University of Liverpool

• Establishment organisation address

  Main Campus

  Liverpool

  L693BX